Four residues of propeptide are essential for precursor folding of nattokinase

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Four residues of propeptide are essential for precursor folding of nattokinase.

Subtilisin propeptide functions as an intramolecular chaperone that guides precursor folding. Nattokinase, a member of subtilisin family, is synthesized as a precursor consisting of a signal peptide, a propeptide, and a subtilisin domain, and the mechanism of its folding remains to be understood. In this study, the essential residues of nattokinase propeptide which contribute to precursor foldi...

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ژورنال

عنوان ژورنال: Acta Biochimica et Biophysica Sinica

سال: 2014

ISSN: 1745-7270,1672-9145

DOI: 10.1093/abbs/gmu093